Entresto

Common use

Entresto is an oral combination heart medication that contains two blood pressure-lowering medications: sacubitril and valsartan. Entresto is used to treat adults with long-lasting (chronic) heart failure to help reduce the risk of death and hospitalization and. Adults who benefit the most from Entresto have a left ventricular ejection fraction (LVEF) below normal (this means the heart cannot pump a normal amount of blood around the body).

Dosage and direction

Take Entresto exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Entresto is taken 2 times each day.

Precautions

Before taking Entresto, tell your doctor about all of your medical conditions, including if you:have a history of hereditary angioedema; have kidney or liver problems; have diabetes; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed.

Contraindications

Do not use Entresto if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Entresto can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Do not take Entresto if you are allergic to sacubitril, valsartan (Diovan), Entresto, any of the inactive ingredients in the tablets or pellets, or if you have ever had a severe allergic reaction, such as angioedema (a serious swelling under the skin) to a blood pressure medication such as: an ACE inhibitor, such as benazepril, captopril, enalapril, or lisinopril, or an ARB, such as candesartan, irbesartan, losartan, or telmisartan.

Possible side effect

The most common side effects of Entresto are: low blood pressure; high potassium levels; cough; dizziness; kidney problems.

Drug interaction

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take: atorvastatin (Lipitor); potassium supplements or a salt substitute; nonsteroidal anti-inflammatory drugs (NSAIDs); lithium; other medicines for high blood pressure or heart problems, such as an ACE inhibitor, ARB, or Aliskiren; a diuretic or "water pill"; NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Missed dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

Overdose

If you take too much Entresto, call your doctor right away or seek emergency medical attention.

Storage

Store Entresto tablets at room temperature between 68°F to 77°F (20°C to 25°C). Protect from moisture. Keep out of the reach of children and pets.