Gleevec
Gleevec (imatinib) is a targeted tyrosine kinase inhibitor used to treat several cancers, most notably Philadelphia chromosome-positive Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL). It also treats Gastrointestinal Stromal Tumors (GIST), dermatofibrosarcoma protuberans, and certain myelodysplastic and myeloproliferative diseases by blocking specific cancer-promoting proteins.
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Product description
Common use
Gleevec is a targeted therapy cancer treatment used to treat specific types of leukemia (blood cancer), bone marrow disorders, skin cancers and certain tumors of the stomach and digestive system.
Gleevec is used to treat specific types of these cancers: Chronic Myeloid (myelogenous) Leukemia (Ph+ CML); Acute Lymphoblastic Leukemia (ALL); Myelodysplastic / Myeloproliferative Diseases (MDS/MPD); Aggressive Systemic Mastocytosis (ASM); Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL); Dermatofibrosarcoma Protuberans (DFSP); Gastrointestinal Stromal Tumors (GIST).
Dosage and direction
Take Gleevec exactly as prescribed by your doctor. Take Gleevec with a meal and a large glass of water. Do not take Gleevec on an empty stomach. If you cannot swallow a tablet whole, you may dissolve it in a glass of water or apple juice to make the pill easier to swallow. Use about 2 ounces of liquid for each 100-milligram tablet, or 7 ounces of liquid for each 400-milligram tablet. Stir the mixture and drink all of it right away. Do not use a broken tablet. Do not stop using Gleevec without your doctor's advice.
Precautions
Tell your doctor if you have ever had: liver disease (especially hepatitis B); kidney disease; underactive thyroid, recent or upcoming thyroid surgery; heart disease, high blood pressure, congestive heart failure; a stomach ulcer or bleeding; diabetes; or chemotherapy. You may need to have a negative pregnancy test before starting this treatment.
Contraindications
You should not use Gleevec if you are allergic to imatinib.
Do not use Gleevec if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 14 days after your last dose.
Do not breast-feed a baby while you are using Gleevec and for at least 1 month after your last dose.
Possible side effect
Common Gleevec side effects may include: fluid retention; nausea, vomiting, stomach pain, diarrhea; joint or muscle pain; skin rash; or feeling tired.
Drug interaction
Tell your doctor about all your current medicines. Many drugs can have interactions with Gleevec, especially: an antibiotic, antifungal, or antiviral medicine; seizure medicine; a blood thinner such as warfarin (Coumadin, Jantoven); or a vitamin or mineral supplement that contains iron.
Missed dose
Take your dose as soon as you can, making sure you also eat a meal and drink a large glass of water. Skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Overdose
Seek emergency medical attention.
Storage
Store at room temperature away from moisture and heat. Keep away from children and pets.