Trintellix

Common use

Trintellix is antidepressant FDA-approved to treat Major Depressive Disorder (MDD) in adults. It is a multimodal medication that increases serotonin levels and acts on serotonin receptors to improve mood and, in some cases, address cognitive dysfunction associated with depression.

Dosage and direction

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. You may take Trintellix with or without food. You may have withdrawal symptoms if you stop using Trintellix suddenly. Ask your doctor before stopping the medicine. Usual adult dose for depression: 10 mg orally once a day.

Precautions

To make sure Trintellix is safe for you, tell your doctor if you have ever had: bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts; glaucoma; seizures or epilepsy; bleeding problems; or low levels of sodium in your blood.
Taking Trintellix in the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, serious lung problems, or other complications in the baby. However, stopping the medicine may not be safe for you. Do not start or stop Trintellix without asking your doctor. Ask a doctor if it is safe to breastfeed while using this medicine.

Contraindications

You should not use Trintellix if you are allergic to vortioxetine.
After you stop taking Trintellix you must wait at least 21 days before you start taking an MAO inhibitor. Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with vortioxetine could cause a serious condition called serotonin syndrome.

Possible side effect

Common Trintellix side effects may include: Nausea; Diarrhea; Dry mouth; Dizziness; Constipation; Vomiting; Gas (flatulence); Itchy skin (pruritus).

Drug interaction

Tell your doctor about all your current medicines. Many drugs can interact with vortioxetine, especially: any other antidepressant; buspirone; fentanyl, tramadol; lithium; rifampin; St. John's wort, tryptophan (sometimes called L-tryptophan); a blood thinner (warfarin, Coumadin, Jantoven); a diuretic or "water pill"; migraine headache medicine (triptans); NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or seizure medicine - carbamazepine, phenytoin.

Missed dose

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Overdose

Seek emergency medical attention.

Storage

Store at room temperature away from moisture and heat. Keep away from children and pets.