Wynzora

Common use

Wynzora is a once-daily, topical, fixed-dose combination cream containing calcipotriene 0.005% (a vitamin D analog) and betamethasone dipropionate 0.064% (a corticosteroid) that may be used to treat plaque psoriasis in adults 18 years of age or older.

Dosage and direction

Wynzora should be applied once daily to the plaques for up to 8 weeks. Rub in gently to ensure the plaques are saturated. Do not use more than 100 g per week. Do not apply an occlusive dressing over the top of Wynzora unless directed by a physician. Do not use it on your face, groin, or armpit, or if skin thinning is present at the treatment site. Not for oral, ophthalmic, or intravaginal use.

Precautions

Tell your doctor if you have ever had: too much calcium in your blood or urine; an adrenal gland disorder; cataracts or glaucoma; liver disease; severe forms of psoriasis (with pus, skin peeling, severe redness); have thinning skin at the treatment site; a skin infection or if you are receiving UV light treatments (phototherapy).
Use of high-potency topical steroid medicine during pregnancy may increase the risk of a low birth weight in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using Wynzora. Ask your doctor about any risks. If you apply betamethasone and calcipotriene to your chest, avoid areas that may come into contact with the baby's mouth.

Contraindications

You should not use Wynzora cream if you are allergic to calcipotriene, betamethasone dipropionate, or any other components of the cream.
Hypercalcemia and hypercalciuria have been observed with the use of topical calcipotriene. If either occurs, discontinue Wynzora until laboratory values of calcium normalize.

Possible side effect

The most common side effects reported with Wynzora include upper respiratory tract infections, headaches, and irritation at the application site.

Drug interaction

Tell your doctor about all your other medicines, especially: any other steroid medicine (such as dexamethasone, fludrocortisone, hydrocortisone, prednisone, triamcinolone, and others); or any other medicine to treat psoriasis.

Missed dose

Apply the cream as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

Overdose

Seek emergency medical attention if anyone has accidentally swallowed the medicine.

Storage

Store between 20°C-25°C (68°F-77°F) and keep away from moisture and heat. Keep the tube tightly closed when not in use. Do not freeze. Keep away from children and pets.